Detection Of Extended Spectrum Of Β-Lactamases In Utis Patients At Raipur Chhattisgarh

Enter obacteriaceae families are capable of producing the extended spectrum beta-lactamase (ESBL) enzyme, which results in highlevels resistance to all beta-lactam antibiotics. For effective antibiotic therapy, stop spread mechanisms, and forepidemiological reasons, their detection is crucial. 53 Gram negative isolates were detected using a standard methodology currentinvestigation, compared various phenotypic methods for ESBL detection. Antibiotic susceptibility testing (AST) was alsoperformed on these isolates. Phenotypic confirmatory Double Disk Synergy Test (30 mm), ModifyDouble Disk, E-Test used further validate presence ESBLs. 20 ESBLs produced case DDST(30 specificity cefepime 84%, rising 86% combination. The sensitivity high forCefepime alone (92%), while combination it 87% 92% with Ceftazidime Cefotaxime. DDST (20mm) 15 ESBLproductions seen once more. MDDST has 94% identified as ESBL. generation 20ESBLs E test, Cefepime showed highest level sensitivity. As result, discovered thatcefepime most cephalosporin detection, followed by cefotaxime, ceftazidime, cefpodoxime.